Bisalbuminemia is an uncommon disorder characterized by bifid albumin peak on serum protein electrophoresis. It is a result of two types of serum albumin that differ in their electrophoretic mobility as a result of splitting of the serum albumin into two components. Bisalbuminemia is of two types, genetic and acquired. and is very rare in Indian population. Genetic bisalbuminemia is quite rare and is inherited in autosomal dominant form. The acquired form of the disease is seen in patients taking ß lactam antibiotics, pancreatic pseudocyst rupture, diabetes mellitus, cirrhosis, hyperamylasemia, nephrotic syndrome, sarcoidosis, Alzheimer disease and plasma cell dyscrasia. Bisalbuminemia is of little diagnostic or therapeutic significance, except that in some cases it might result in altered binding of steroid hormones and thyroxine and not misinterpreted as an abnormal globulin peak specifically in cases of plasma cell dyscrasia. The described case here is a 67-year-old female with multiple myeloma who was consolidated with auto HSCT outside. The patient came to our center for follow up and showed bifid albumin peak on serum protein electrophoresis. The patient had no other comorbidities which may have attributed to this disorder and was taken as an incidental finding with little diagnostic or therapeutic significance.
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Last modified: 21/10/2017